SomniTR™ | 30 tablets
SomniTR™ is a delayed-released formula, designed to release 1mg of melatonin initially and 1mg three hours later, to help promote the ability to stay asleep.

SomniTR™ supports melatonin production and levels through multiple steps in the Serotonin-to-melatonin pathway, and also influences inhibitory GABAergic activity.

*use only under direct supervision of a licensed healthcare provider

SomniTR™ is a delayed-released formula, designed to release 1mg of melatonin initially and 1mg three hours later, to help promote the ability to stay asleep. SomniTR™ supports melatonin production and levels through multiple steps in the Serotonin-to-melatonin pathway, and also influences inhibitory GABAergic activity.
Coleus forskohlii: A source of forskolin that increases cAMP, which promotes melatonin synthesis by contributing to the activity of Serotonin N-acetyltransferase, the enzyme that metabolizes Serotonin into the intermediate N-acetylserotonin.

Lactium®: Excellent GABA-A receptor agonist; small, hypoallergenic peptide derived from dairy.

Pantethine: Immediate precursor to acetyl coenzyme A, acetyl donor in the production of N-acetylserotonin, the precursor to melatonin.

Melatonin: Neurohormone involved with circadian rhythm regulation and sleep induction.

also influences inhibitory GABAergic activity.

Melatonin deficiency is involved in prolonged sleep latency and the inability to stay asleep, circadian rhythm disorders, and jet lag. Melatonin has also been shown to reduce ACTH-stimulated cortisol production that may interfere with sleep. Disordered circadian rhythm is being studied as another cause for increased appetite stimulation and weight gain. The melatonin in SomniTR™ is delayed-released to provide sustained levels for up to eight hours. Besides melatonin, SomniTR™ combines support for GABA-A receptor sites. GABA-A agonists have shown to improve quality of sleep. Other ingredients are added to the formula to support melatonin synthesis.

SomniTR™ provides support for patients with sleep problems in conjunction with Lentra™ and/or Tranquilent™. It helps in supporting melatonin production and may help improve decreased GABA binding.

History of major depressive disorder.

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The Natural Process

The biosynthesis of melatonin (Fig.1) is initiated by the uptake of the essential amino acid tryptophan into pineal parenchymal cells. Tryptophan is the least abundant of essential amino acids in normal diets. It is converted to another amino acid, 5-hydroxytryptophan, through the action of the SomniTR pathway-01enzyme tryptophan hydroxylase and then to 5-hydroxytryptamine (serotonin) by the enzyme aromatic amino acid decarboxylase.

Serotonin concentrations are higher in the pineal than in any other organ or in any brain region. They exhibit a striking diurnal rhythm remaining at a maximum level during the daylight hours and falling by more than 80% soon after the onset of darkness as the serotonin is converted to melatonin, 5-hydroxytryptophol and other methoxyindoles.

Serotonin’s conversion to melatonin involves two enzymes that are characteristic of the pineal : SNAT (serotonin-N-acetyltransferase) which converts the serotonin to N-acetylserotonin, and HIOMT (hydroxyindole-O-methyltrasferase) which trasfers a methyl group from S-adenosylmethionine to the 5-hydroxyl of the N-acetylserotonin.

The activities of both enzymes rise soon after the onset of darkness because of the enhanced release of norepinephrine from sympathetic neurons terminating on the pineal parenchymal cells. (source)

Patient Testimonial

Betty | Arizona

SomniTr was recommended by my doctor to give me a restful night’s sleep. I was waking up several times during the night and having difficulty going back to sleep, which left me feeling tired the next day. SomniTR Delayed-Release Sleep Formula allows me to wake up if I need to go to the bathroom during the night, but enables me to go right back to sleep. As the label suggests, allow for a full 8 hours of sleep. When I awake, I am fully rested and ready to get going. I have been using SomniTR for several years,

Patient Testimonial

IDgirl | Idaho

I’ve been using SomniTR for about 5 years per my Naturopath’s suggestion. I have trouble sleeping if I run out of it, but it’s not addictive. It just helps you sleep.