SomniTR^TM

A deficiency in melatonin levels can contribute to prolonged sleep latency, inability to stay asleep, disruption to circadian rhythms and jet lag.¹ Disordered circadian rhythm is hypothesized to contribute to increased appetite and weight gain.² Melatonin also has the capability to reduce ACTH-stimulated cortisol production that has been found to interrupt sleep.²

The delayed–release melatonin in SomniTR provides sustained levels for up to eight hours.

SomniTR also provides support for GABA-A receptor sites.* GABA-A agonists, such as Lactium have been shown to improve quality of sleep.*³ ForsLean supports cAMP⁴ while pantothenic acid supports acetyl coenzyme A,⁵ both of which are important in melatonin synthesis.*⁶

SomniTR provides support for patients with sleeping problems.* It may be taken in conjunction with Lentra™, Prolent™ and/or Tranquilent™.

SomniTR contains ingredients that support melatonin production by supplementing multiple steps in the serotonin-to-melatonin pathway or influence inhibitory GABAergic activity.* The tablet offers both immediate-release and delayed-release melaton into keep melatonin levels steady throughout the sleep cycle. 

Lactium® Acts as a GABA-A receptor agonist.*⁷ Lactium has been shown to decrease stress-related symptoms in women⁸ and significantly improve sleep quality.*³

ForsLean® (standardized to 20% forskolin) a source of forskolin that increases cAMP.*⁴ Serotonin N-acetyltransferase requires cAMP to metabolize serotonin to N-acetylserotonin, the immediate precursor to melatonin.⁶

Pantethine Precursor to acetyl coenzyme A.*² Production of N-acetylserotonin requires acetyl coenzyme A.⁶

Calcium (as Dicalcium Phosphate) potentiates the effects of cAMP.* Serotonin N-acetyltransferase requires cAMP to convert serotonin to the precursor to melatonin.⁵

Melatonin is a neurohormone involved with circadian rhythm regulation and sleep induction.*²

Serving Size: 1 Tablet
Servings Per Container: 30 Tablets

SomniTR™ Formula  304mg  
Pantothenic Acid (as pantethine)
Calcium (as Dicalcium Phosphate)
ForsLean® (Coleus forskohlii extract) (standardized for 20% forskolin) (root)
Lactium®
Melatonin

Lactium® is a registered trademark used under license and is protected under U.S. patent #5,846,939.

ForsLean® is a registered trademark of Sabinsa Corporation and is the only Coleus forskohlii preparation supported commonly by Patent.

GABA is vital for: 

• Sleep⁹
  
• Calm and relaxation⁹
• Mood⁹
  
• Regulating excitability⁹
  

Melatonin is critical for: 

• Sleep^1,6

1. Zisapel N. British Journal of Pharmacology. 2018;175: 3190-3199.
2. Hardeland R, et al. Progress in Neurobiology. 2011; 93(3), 350-384.11. 
3. de Saint-Hilaire ZD, et al. The Open Sleep Journal. 2009;3, 26-32.  
4. Allen DO and Quesenberry JT. Journal of Pharmacology and Experimental Therapeutics.1988;244(3):852-858.
5. Horvath Z and Vecsel L. Journal of Evidence-based Complementary & Alternative Medicine. 2011;16(1):21-28. 
6. Klein DC, et al. Recent. Prog. Horm. 1997;52:307-357. 
7. Miclo L, et al. The FASEB Journal express article. Published online 2001 Jun 8.
8. Kim JH, et al. European Journal of Clinical Nutrition. 2007;61:536-541.
9. Ngo D and Vo TS. Molecules. 2019;24(15):2678.