A bottle of Contegra- a neurotransmitter supplement
Targeted Nutritional support™


HPA Balancing Formula*

Contegra™ is a broad-spectrum support formula for those who complain of anxiousness yet are fatigued due to poor sleep quality. Ingredients support inhibitory and excitatory neurotransmitter production, adrenal function, and methylation pathways.* It also supplies cofactor and/or phosphorylated forms of B vitamins critical for proper neurotransmitter function.* 

Encapsulating The art & science of functional nutrition™

Formula Overview

Ingredients in Contegra™ support balance within the hypothalamic-pituitary-adrenal (HPA) axis.* Contegra also includes ingredients that support inhibitory activity as well as ingredients for excitatory activity to maintain inhibitory and excitatory balance.* Healthy methylation is supported by multiple biologically active ingredients.* 

The NeuroSupport Blend™ (NSB) is designed to enhance absorption, supporting the impact of the ingredients.* 

Contegra offers a gentle excitatory support by incorporating ingredients to balance stimulating and excitatory pathway activity. The dose of ingredients supporting excitatory neurotransmitters is higher in Procite-D™ than in Contegra

L-theanine as Suntheanine® (standardized to >99%) L-Theanine intake is shown to restore balanced relaxation by balancing multiple internal mechanisms, leading to increased healthy GABA and decreased norepinephrine activity. *1,2

N-Acetyl-L-Tyrosine Precursor to L-DOPA, the direct precursor to the catecholamines dopamine, norepinephrine and epinephrine.* 

Siberian Ginseng Extract Eleutherococcus senticosus, an adaptogen thought to attenuate the effects of stress and fatigue.*3,4

Betaine (TrimethylglycineMethylating agent that supports SAMe production/recycling.*5 SAMe is a co-factor in epinephrine synthesisAlso acts as a source of glycine, an inhibitory amino acid neurotransmitter.* 

Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®) Cofactor in methylation reactions essential for synthesis of dopamine, norepinephrine and epinephrine.* 

Vitamin B6 (as pyridoxal-5’-phosphate): Active form of B6. Cofactor in conversion of L-DOPA to dopamine.* 

Vitamin B12 (as Methylcobalamin) Coenzyme form of Vitamin B12.* Methyl donor.* 

Pantothenic acid (as pantethineBiologically active form of Vitamin B5; adrenal support nutrient.* 

NeuroSupport Blend (NSB) Proprietary mixture composed of Bioperine® and plant-based enzymes designed to maximize nutrient absorption.*

Serving Size: 1 Capsule
Servings per Container: 60 Capsules

Contegra™ Formula  385.85 mg  
Vitamin B6 (as pyridoxal-5-phosphate)
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
Vitamin B12 (as methylcobalamin)
Pantothenic Acid (as pantethine)
Betaine (Trimethylglycine)
L-theanine (as Suntheanine®)
N-Acetyl L-Tyrosine
Siberian Ginseng Extract  (Eleutherococcus senticosus) (stem)

NSB™ Proprietary Blend  102.5mg
BioPerine® (Black Pepper Extract) (standardized to 95% piperine) (Piper nigrum) (fruit)

NSB logo
NSB™ is a trademark of Sanesco International Inc.

BioPerine Logo
BioPerine® is a registered trademark and a product of Sabinsa Corp.

Contegra™ 1
Suntheanine® brand L-Theanine is a registered trademark of Taiyo International, Inc. Suntheanine® is Generally Recognized as Safe (GRAS) & is Non-GMO Project Verified.

Contegra™ 2  
Quatrefolic® is a registered trademark of Gnosis S.p.A, U.S. Patent No. 7,947,662

Inhibitory and excitatory neurotransmitter balance is critical for optimal wellness: 

  • Maintaining mental and emotional health 
  • Energy 
  • Balanced calm and relaxation 
  • A healthy stress response
  • Focus 
  • Healthy cognitive function
  • Weight management balance
  • Healthy blood sugar regulation 


  1. Nathan PJ, et al. 2006. J Herb Pharmacother. 6:21–30.
  2. Kimura and Morata. Chem Parhm Bull (Tokyo). 1986. Jul; 34 (7) 3053.7.

  3. Kimura Y, Sumiyoshi M. J Ethnopharmacol. 2004 Dec ;95(2-3):447-53. 

  4. Arouca A and Grassi-Kassisse DM. Health. 2013;5(9):1509-1515.  
  5. Kempson SA, et al Cell Physiol Biochem2013;32(suppl 1):32-40.
A bottle of Contegra- a neurotransmitter supplement

Featured Ingredients


L-Theanine (as Suntheanine®)

Amino Acid

Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA and decreasing norepinephrine*

Procite-D molecule


Amino Acid

Precursor to L-DOPA, the direct precursor to the catecholamines dopamine, norepinephrine and epinephrine.*

Siberian Ginseng - Contegra

Siberian Ginseng Extract

Herbal Ingredient

Eleutherococcus senticosus, an adaptogen thought to attenuate the effects of stress and fatigue.*


What They're Saying

What I noticed right away about the formulas was that they had the NSB™ (NeuroSupport Blend) in them. So many of our patients with adrenal issues also have gut issues, and they’re malabsorbing. Getting them on a product that's going to actually be bioavailable was super important.

Kelly Engelmann, CFNP
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Inhibitory Neurotransmitter


One of our feel-good neurotransmitters; Low levels of serotonin may relate to occasional symptoms like moodiness, sleep issues, and carb cravings.