Prolent™ | 60 capsules
Prolent™ helps rebuild and support inhibitory neurotransmission in general, including support for GABA receptors and glycine. It also supplies cofactor Vitamin B6 as Pyridoxal-5’-Phosphate.

*use only under direct supervision of a licensed healthcare provider

Prolent™ supports inhibitory neurotransmission by functioning to primarily rebuild serotonin stores, while supporting GABA receptors and glycine.

L-theanine (as Suntheanine®): GABA-A receptor agonist; anxiolytic*

NSB™: Nutrient delivery system

Glycine: Glycine is a non-essential amino acid derived from serine. Glycine functions as an inhibitory neurotransmitter in the body, and is capable of readily crossing the Blood-Brain Barrier because of its small size. The primary role of glycine is the building of proteins. [14]

5-HTP: 5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid, and a metabolite of the protein building block, L tryptophan. 5-HTP is the direct precursor in the biosynthesis of serotonin. It is commercially synthesized from the seeds of the African plant Griffonia simplicifolia. [1]


Prolent™ is used in the Initial, Restoration, and Maintenance phases to rebuild or maintain the inhibitory system of neurotransmitters or to continue inhibitory support while rebuilding the excitatory system.

Use when serotonin function is inadequate to control elevated excitatory neurotransmitters, particularly norepinephrine and glutamate. In the scientific literature, insufficient serotonin is associated with conditions such as depression, insomnia, anxiety, carbohydrate cravings, menopausal symptoms, and increased perception of pain. Serotonin helps restore GABA inhibitory function.

When GABA is elevated and serotonin is low, raising serotonin can help to normalize GABA.

Prolent™ may be combined with Lentra™, SomniTR™, or Tranquilent™ for added inhibitory support. In conjunction with excitatory support, Prolent™ helps prevent over-excitation, especially when patients indicate symptoms of anxiety, nervousness, or agitated depression.

No specific contraindications are known other than for individuals who are hypersensitive to any of the Prolent™ ingredients. Building up for a week or two with smaller doses is advisable to avoid loose stools that occur in about 10% of cases upon initial contact with 5-HTP.

Featured Ingredients


B6 Vitamin


5-HTP from Griffonia simplicifolia

The Natural Process

An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. This review provides a brief overview of the role of L-tryptophan in protein synthesis and a number of other metabolic functions. With emphasis on L-tryptophan’s role in synthesis of brain serotonin, details are provided on the research uses of L-tryptophan, particularly L-tryptophan depletion, and on clinical trials that have been conducted using L-tryptophanProlent pathway-01 supplementation.

The ability to change the rates of serotonin synthesis in the brain by manipulating concentrations of serum tryptophan is the foundation of much research. As the sole precursor of serotonin, experimental research has shown that L-tryptophan’s role in brain serotonin synthesis is an important factor involved in mood, behavior, and cognition. Furthermore, clinical trials have provided some initial evidence of L-tryptophan’s efficacy for treatment of psychiatric disorders, particularly when used in combination with other therapeutic agents. (source)

Patient Testimonial

Deb | Ohio

Prolent worked well enough that upon retesting in 3 months, taken as a 1/d dose in concert w/Contegra and Lentra, I had gone from significantly below normal levels to 3x normal levels. No side effects. Like it – have dropped back on the dosage and will see how retesting (with Sanesco Labs) goes.

Patient Testimonial

Deanna | California

Prolent was recommended by my doctor about 5 years ago. It has helped my “fog” which I had since my early 20s. It is the only thing I have found to work