Lentra™ | 30 & 60 capsules
Lentra™ is a natural anxiolytic formula targeting GABAA receptors. It is a highly effective product which activates inhibitory neurotransmission and induces relaxation and restfulness, without inducing sedation.

*use only under direct supervision of a licensed healthcare provider

Lentra™ is a natural anxiolytic formula targeting GABA-A receptors. It is a highly effective product which activates inhibitory neurotransmission and induces relaxation and restfulness, without inducing sedation.

Magnesium bisglycinate: Source of taurine, an inhibitory amino acid molecularly bound to magnesium; GABA-A receptor; agonist and inhibitory neurotransmitter; membrane stabilization agent.

L-theanine (as Suntheanine®): GABA-A receptor agonist; anxiolytic.

NSB™: Nutrient delivery system.

Lactium®: Excellent GABA-A receptor agonist; small, hypoallergenic peptide derived from dairy.

Use in any phase when support is needed for the inhibitory system, particularly GABA. For example, use when an assessment shows GABA below reference range or is insufficient to control excitatory neurotransmitter levels (glutamate or any of the catecholamines).

Research shows deficient GABA levels or function contributes to anxiety, insomnia, nervousness, irritability, and PMS symptoms. GABA functions synergistically with progesterone for a balanced and calming effect during PMS and menopause. GABA levels may elevate to compensate for low serotonin. When serotonin increases due to supplementation, GABA levels often normalize.

Lentra™ contributes, along with Prolent™, to re-balancing the inhibitory system that keeps us calm.

Combined with Prolent™ or Tranquilent™, increases available inhibitory support. Lentra™ may be recommended in combination with SomniTR™ or Tranquilent™ to promote sleep.

No specific contraindications known other than for individuals who are hypersensitive to any of the Lentra™ ingredients.

Featured Ingredients


L-Theanine is an amino acid contained in green tea leaves, with similar structure and properties to glutamine and the excitatory neurotransmitter



Discovered in Ingredia’s laboratories, it will help you to gently counteract a loss of appetite, snacking, loss of libido, sleep troubles, mood swings, concentration and memory problems, etc.*

The Natural Process

Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. Three such carriers have been cloned and characterized, referred to as ASCT2, GlnT and SN1. They are differentially expressed in brain cells; ASCT2 and SN1 Lentra pathway-01being astrocytic and GlnT being neuronal. They play different roles in glutamine influx and efflux and hence control the availability of glutamine in glutamatergic and GABAergic neurons.

The neurotransmitter glutamate can be synthesized from glutamine by the action of phosphate-activated glutaminase. It appears, however, that glutamate derived from glutamine
via this route is produced intramitochondrially and may subsequently undergo a transamination catalyzed by the mitochondrial isoform of aspartate aminotransferase. The α-ketoglutarate thus formed is translocated out of the mitochondria by the dicarboxylate carrier and transaminated in the cytoplasm by the cytoplasmic isoform of aspartate aminotransferase. Alternatively, glutamate may be formed from α-ketoglutarate and alanine catalyzed by alanine aminotransferase. This cytoplasmic glutamate is transported into vesicles by vesicular glutamate transporters. Three vesicular glutamate transporters have been cloned and they exhibit differential expression in glutamatergic neurons in various brain regions. This has important implications with regard to characterization of subpopulations of glutamatergic neurons. Glutamate metabolism, which to a large extent takes place in astroglial cells, is catalyzed either by glutamine synthetase or glutamate dehydrogenase.

The inhibitors for the enzymes involved in glutamate biosynthesis are not absolutely specific. This is particularly serious for aminooxyacetic acid, which at high concentrations will inhibit all pyridoxal phosphate-dependent enzymes. Another problem with amino-oxyacetic acid is that it potently inhibits both glutamate decarboxylase and GABA-transaminase (see Table below). Even methionine sulfoximine, which is proven to be an extremely useful tool to study the functional importance of glutamine synthetase, is not strictly specific for this enzyme, but also inhibits, for example, α glutamylcysteine synthetase, a key enzyme in the biosynthesis of glutathione. Therefore, these inhibitors must be used with caution.

The neurotransmitter GABA is formed from glutamate by the action of glutamate decarboxylase. It appears that glutamine serves as the precursor for glutamate, making phosphate-activated glutaminase, an important enzyme for GABA synthesis as well. Recent studies of these processes, using [13C]-labeled substrates and [13C] NMR spectroscopy to follow the metabolic fate of individual C-atoms, have suggested that this biosynthetic route is somewhat more complex than previously thought. It appears that glutamate formed from glutamine may be metabolized in the tricarboxylic acid (TCA) cycle prior to its conversion to GABA, which may allow new alternative regulatory mechanisms. Moreover, it appears that this pathway involving TCA cycle activity is differentially involved in the biosynthesis of GABA destined for the cytoplasmic and vesicular pools, respectively. GABA is metabolized by the action of GABA-transaminase, which is a ubiquitous enzyme being present in GABAergic neurons as well as other types of neurons and astrocytes. Inhibitors of this enzyme generally exhibit anticonvulsant actions. (source)

Patient Testimonial

Carol | Boston

I took Lentra as part of a regimen based on my body chemistry done by my naturopath doctor. Because I was taking a bunch of stuff, I couldn’t tell what it did for me. I was weaning off supplements and noticed that when Lentra was removed, I was moodier and got frustrated easier. Back on it, and life is good again. It is amazing how little changes make such a difference.

Patient Testimonial

Jan | Sacramento

I feel normal with Lentra. Without it there is more anxiety and frustration and less patience. Lentra allows me to be more “even keeled” in day to day activities and experiences.