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Neurotransmitters and Motivation: Achieve Your Goals


Whether you are looking to maintain a new year’s resolution or achieve your dreams, maintaining motivation is crucial. Balancing neurotransmitters can help you maintain motivation and delay gratification so that your goals are easier to achieve.

Neurotransmitters Important for Maintaining Motivation

Motivational salience is a term used in the fields of psychology and neuroscience to describe how our brains choose what to pay attention to. We are surrounded by so much stimuli that we can’t process all of it at once. Things that are salient are most important for survival or success. For example, food, attractive members of the opposite sex, and money are all salient stimuli for humans. These are the things that motivate us, things that we work to achieve.

Norepinephrine and dopamine are catecholamine neurotransmitters important for determining salience and maintaining motivation.[1],[2] By studying mice, scientists have determined that the level of norepinephrine released in the prefrontal cortex (PFC) of the brain is directly proportional to the level of salience for a particular stimulus.[3] That is to say, more norepinephrine was released when the mice were exposed to highly desirable food than when they were exposed to less desirable food.[4]

Dopamine in the PFC is important for learning, decision making, and responding to salient reward or punishment.[5] Researchers have found that when dopamine signalling is disrupted in the human brain, the ability to change our behavior in order to earn rewards is decreased.[6] The capacity to distinguish between salient and non-salient outcomes is diminished.[7]

So, how do all these lab experiments apply to goals? Goals must have salience.  If we want to be able to stay motivated in achieving our goals, research shows that optimal levels of norepinephrine and dopamine are important.

Neurotransmitters Important for Delaying Gratification

Motivation is certainly important in achieving your goals, but so is the ability to delay gratification. Eating a piece of cake makes you feel good in the moment, but resisting the cake to achieve weight loss goals is better in the long run. Delay discounting is a term that describes the phenomenon of devaluing a reward based on the amount of time it takes to receive it. People who show increased delay discounting, or choose smaller more immediate rewards over larger rewards in the future, are typically more impulsive.[8],[9] They have a reduced ability to delay gratification and optimize their decisions involving risk and reward.

A group of researchers found that rats with lesions in the DLS (a region densely packed with dopaminergic neurons), chose small immediate rewards more frequently than rats without these lesions.[10] This finding suggests that dopamine plays a crucial role in regulating decision making and delaying gratification.[11]  The amount of serotonin in the central nervous system is also associated with the ability to delay gratification.[12] When researchers used tryptophan depletion to decrease serotonin levels in human subjects, they found that it increased impulsivity.[13] People with low serotonin showed more delay discounting than controls.[14]

These studies tell us that adequate serotonin and dopamine are necessary for delaying gratification—an important aspect of achieving your goals.

Whether your resolution is to eat healthier, quit smoking, or save money, balancing dopamine, norepinephrine, and serotonin is an important step in setting up your brain for success.

Don’t Let Neurotransmitter Imbalance Sabotage You

Find out if imbalances in dopamine, norepinephrine, or serotonin are sabotaging you from within. Find a Sanesco provider to have your neurotransmitters tested and balanced or become a provider.



[1] Shiner T, Symmonds M, Guitart-Masip M, et. al. (2015). Dopamine, Salience, and Response Set Shifting in Prefrontal Cortex. Cerebral Cortex 25:3629–3639
[2] Ventura R, Latagliata EC, Morrone C, et. al. (2008) Prefrontal Norepinephrine Determines Attribution of ‘‘High’’ Motivational Salience. PLoS ONE 3(8): e3044. doi:10.1371/journal.pone.0003044
[3] Ibid.
[4] Ibid.
[5] Shiner op. cit.
[6] Ibid.
[7] Ibid.
[8] Tedford SE, Persons AL, & Napier TC. (2015). Dopaminergic Lesions of the Dorsolateral Striatum in Rats Increase Delay Discounting in an Impulsive Choice Task. PLoS ONE 10(4): e0122063.doi:10.1371/journal.pone.0122063
[9] Schweighofer N, Bertin M, Shishida K, et. al. (2008). Low-Serotonin Levels Increase Delayed Reward Discounting in Humans. The Journal of Neuroscience 28(17):4528–4532.
[10] Tedford op. cit.
[11] Ibid.
[12] Schweighofer op. cit.
[13] Ibid.
[14] Ibid.

Clinical Contributor

Marina Braine

Clinical Support Specialist at Sanesco International, Inc.

Marina Braine is a Clinical Support Specialist at Sanesco. She graduated from UNC-Asheville with her Bachelors of Science in Biology with a minor in French. She likes to keep active by hiking, running, and contra dancing around Asheville.

Ramona Richard, MS, NC

Ramona Richard, MS, NC

Ramona Richard graduated with honors from the University of California with a Bachelor’s Degree in psychology and graduated summa cum laude with a Master’s Degree in Health and Nutrition Education. She also holds a Standard Designated Teaching Credential from the State of California, is a California state-certified Nutrition Consultant and a member of the National Association of Nutrition Professionals.

Ramona has participated in nutrition education in both public and private venues, including high school and college presentations, radio and public speaking for the past 20 years. She is the owner of Radiance, a nutrition consulting company, the Director of Education for Sanesco International, and a medical technical writer.

Disclaimer: The information provided is only intended to be general educational information to the public. It does not constitute medical advice. If you have specific questions about any medical matter or if you are suffering from any medical condition, you should consult your doctor or other professional healthcare provider.

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