Contegra^TM

Ingredients in Contegra™ support balance within the hypothalamic-pituitary-adrenal-thyroid (HPA-T) axis.* Contegra also includes ingredients that support inhibitory activity as well as ingredients for excitatory activity to maintain inhibitory and excitatory balance.* Healthy methylation is supported by multiple biologically active ingredients.* 

The NeuroSupport Blend™ (NSB) enhances absorption.* Improved absorption allows for smaller doses and fewer capsules. 

Contegra is often suggested after inhibitory support (Prolent™, Lentra™, Tranquilent™) has begun and offers a gentle transition to excitatory support. The dose of ingredients supporting excitatory neurotransmitters is higher in Procite-D™ than in Contegra. Contegra may be used in the Initial, Restoration or Maintenance phases on the path to patient wellness.

L-theanine as Suntheanine® (standardized to >99%) Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA, and decreasing norepinephrine levels in the brain.*^1,2

N-Acetyl-L-Tyrosine Precursor to L-DOPA, the direct precursor to the catecholamines dopamine, norepinephrine and epinephrine.* Acetylated for enhanced bioavailability. 

Siberian Ginseng Extract (standardized to 0.8% eleutherosides) Eleutherococcus senticosus, an adaptogen thought to attenuate the effects of stress and fatigue.*^3,4

Iodine (as potassium iodide) Essential component of T3 and T4 thyroid hormones.⁵

Betaine (Trimethylglycine) Methylating agent that supports SAMe production/recycling.*⁶ SAMe is a co-factor in epinephrine synthesis. Also acts as a source of glycine, an inhibitory amino acid neurotransmitter.* 

Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®) Cofactor in methylation reactions essential for synthesis of dopamine, norepinephrine and epinephrine.* 

Vitamin B6 (as pyridoxal-5’-phosphate): Active form of B6. Cofactor in conversion of L-DOPA to dopamine.* 

Vitamin B12 (as Methylcobalamin) Coenzyme form of Vitamin B12.* Methyl donor.* 

Pantothenic acid (as pantethine) Biologically active form of Vitamin B5; adrenal support nutrient.* 

NeuroSupport Blend™ (NSB) Proprietary mixture composed of Bioperine® and plant-based enzymes clinically proven to maximize nutrient absorption.*

Serving Size: 1 Capsule
Servings per Container: 60 Capsules

Contegra™ Formula  385.85 mg  
Vitamin B6 (as pyridoxal-5-phosphate)
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
Vitamin B12 (as methylcobalamin)
Pantothenic Acid (as pantethine)
Iodine (as potassium iodide)
Betaine (Trimethylglycine)
L-theanine (as Suntheanine®)
N-Acetyl L-Tyrosine
Siberian Ginseng Extract (std. to 0.8% eleutherosides) (Eleutherococcus senticosus) (stem)

NSB™ Proprietary Blend  102.5mg
BioPerine® (Black Pepper Extract) (standardized to 95% piperine) (Piper nigrum) (fruit)
Protease
Amylase
Lipase

NSB™ is a trademark of Sanesco International Inc.

BioPerine® is a registered trademark and a product of Sabinsa Corp.

Suntheanine® brand L-Theanine is a registered trademark of Taiyo International, Inc. Suntheanine® is Generally Recognized as Safe (GRAS) & is Non-GMO Project Verified.

 
Quatrefolic® is a registered trademark of Gnosis S.p.A, U.S. Patent No. 7,947,662

Inhibitory and excitatory neurotransmitter balance is critical for: 

• Mental and emotional health 
• Energy 
• Calm and relaxation 

Adrenal health is important for: 

• Energy 
• Stress response 
• Resilience 
• Focus 
• Weight management 
• Menopause & andropause 
• Healthy blood sugar regulation 
• Mental and emotional health  

Thyroid health plays important roles in: 

• Weight management⁷
  
• Energy⁷
• Digestion⁷
  
• Mood⁷ 

1. Eschenauer G and Sweet BV. Am J Healthy-Syst Pharm. 2006 Jan 1;63(1):26-30.  
2. Kakuda T, et al. Biosci Biotechnol Biochem. 2002;66(12):2683–2686. 
3. Kimura Y, Sumiyoshi M. J Ethnopharmacol. 2004 Dec ;95(2-3):447-53. 
4. Arouca A and Grassi-Kassisse DM. Health. 2013;5(9):1509-1515. 
5. Iodine. (n.d.). Office of Dietary Supplements (ODS). Retrieved July 1, 2011, from http://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/ 
6. Kempson SA, et al Cell Physiol Biochem. 2013;32(suppl 1):32-40.
7. Thinking About Your Thyroid. News in Health. 2015 Sept. Accessed on Aug. 14, 2019. https://newsinhealth.nih.gov/2015/09/thinking-about-your-thyroid