What I noticed right away about the formulas was that they had the NSB™ (NeuroSupport Blend) in them. So many of our patients with adrenal issues also have gut issues, and they’re malabsorbing. Getting them on a product that's going to actually be bioavailable was super important.
Targeted Nutritional Therapy™
HPA-T Balancing Formula*
Contegra™ is a broad-spectrum support formula for those who complain of anxiousness yet are fatigued due to poor sleep quality.
Ingredients support inhibitory and excitatory neurotransmitter production, adrenal and thyroid function, and methylation pathways.* It also supplies cofactor and/or phosphorylated forms of B vitamins critical for proper neurotransmitter function.*
Encapsulating The art & science of functional nutrition™
Ingredients in Contegra™ support balance within the hypothalamic-pituitary-adrenal-thyroid (HPA-T) axis.* Contegra also includes ingredients that support inhibitory activity as well as ingredients for excitatory activity to maintain inhibitory and excitatory balance.* Healthy methylation is supported by multiple biologically active ingredients.*
The NeuroSupport Blend™ (NSB) enhances absorption.* Improved absorption allows for smaller doses and fewer capsules.
Contegra is often suggested after inhibitory support (Prolent™, Lentra™, Tranquilent™) has begun and offers a gentle transition to excitatory support. The dose of ingredients supporting excitatory neurotransmitters is higher in Procite-D™ than in Contegra. Contegra may be used in the Initial, Restoration or Maintenance phases on the path to patient wellness.
L-theanine as Suntheanine® (standardized to >99%) Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA, and decreasing norepinephrine levels in the brain.*1,2
N-Acetyl-L-Tyrosine Precursor to L-DOPA, the direct precursor to the catecholamines dopamine, norepinephrine and epinephrine.* Acetylated for enhanced bioavailability.
Siberian Ginseng Extract (standardized to 0.8% eleutherosides) Eleutherococcus senticosus, an adaptogen thought to attenuate the effects of stress and fatigue.*3,4
Iodine (as potassium iodide) Essential component of T3 and T4 thyroid hormones.5
Betaine (Trimethylglycine) Methylating agent that supports SAMe production/recycling.*6 SAMe is a co-factor in epinephrine synthesis. Also acts as a source of glycine, an inhibitory amino acid neurotransmitter.*
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®) Cofactor in methylation reactions essential for synthesis of dopamine, norepinephrine and epinephrine.*
Vitamin B6 (as pyridoxal-5’-phosphate): Active form of B6. Cofactor in conversion of L-DOPA to dopamine.*
Vitamin B12 (as Methylcobalamin) Coenzyme form of Vitamin B12.* Methyl donor.*
Pantothenic acid (as pantethine) Biologically active form of Vitamin B5; adrenal support nutrient.*
NeuroSupport Blend™ (NSB) Proprietary mixture composed of Bioperine® and plant-based enzymes clinically proven to maximize nutrient absorption.*
Serving Size: 1 Capsule
Servings per Container: 60 Capsules
Contegra™ Formula 385.85 mg
Vitamin B6 (as pyridoxal-5-phosphate)
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
Vitamin B12 (as methylcobalamin)
Pantothenic Acid (as pantethine)
Iodine (as potassium iodide)
L-theanine (as Suntheanine®)
Siberian Ginseng Extract (std. to 0.8% eleutherosides) (Eleutherococcus senticosus) (stem)
NSB™ Proprietary Blend 102.5mg
BioPerine® (Black Pepper Extract) (standardized to 95% piperine) (Piper nigrum) (fruit)
NSB™ is a trademark of Sanesco International Inc.
BioPerine® is a registered trademark and a product of Sabinsa Corp.
Suntheanine® brand L-Theanine is a registered trademark of Taiyo International, Inc. Suntheanine® is Generally Recognized as Safe (GRAS) & is Non-GMO Project Verified.
Quatrefolic® is a registered trademark of Gnosis S.p.A, U.S. Patent No. 7,947,662
Inhibitory and excitatory neurotransmitter balance is critical for:
- Mental and emotional health
- Calm and relaxation
Adrenal health is important for:
- Stress response
- Weight management
- Menopause & andropause
- Healthy blood sugar regulation
- Mental and emotional health
Thyroid health plays important roles in:
- Weight management7
- Eschenauer G and Sweet BV. Am J Healthy-Syst Pharm. 2006 Jan 1;63(1):26-30.
- Kakuda T, et al. Biosci Biotechnol Biochem. 2002;66(12):2683–2686.
- Kimura Y, Sumiyoshi M. J Ethnopharmacol. 2004 Dec ;95(2-3):447-53.
- Arouca A and Grassi-Kassisse DM. Health. 2013;5(9):1509-1515.
- Iodine. (n.d.). Office of Dietary Supplements (ODS). Retrieved July 1, 2011, from http://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/
- Kempson SA, et al Cell Physiol Biochem. 2013;32(suppl 1):32-40.
- Thinking About Your Thyroid. News in Health. 2015 Sept. Accessed on Aug. 14, 2019. https://newsinhealth.nih.gov/2015/09/thinking-about-your-thyroid
THE 'WIRED & TIRED' FORMULA
L-Theanine (as Suntheanine®)
Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA and decreasing norepinephrine*
Precursor to L-DOPA, the direct precursor to the catecholamines dopamine, norepinephrine and epinephrine.*
Siberian Ginseng Extract
Eleutherococcus senticosus, an adaptogen thought to attenuate the effects of stress and fatigue.*