What I noticed right away about the formulas was that they had the NSB™ (NeuroSupport Blend) in them. So many of our patients with adrenal issues also have gut issues, and they’re malabsorbing. Getting them on a product that's going to actually be bioavailable was super important.
Encapsulating The art & science of functional nutrition™
Ingredients in Contegra™ support balance within the hypothalamic-pituitary-adrenal-thyroid (HPA-T) axis.* Contegra also includes ingredients that support inhibitory activity as well as ingredients for excitatory activity to maintain inhibitory and excitatory balance.* Healthy methylation is supported by multiple biologically active ingredients.*
The NeuroSupport Blend™ (NSB) enhances absorption.* Improved absorption allows for smaller doses and fewer capsules.
Contegra is often suggested after inhibitory support (Prolent™, Lentra™, Tranquilent™) has begun and offers a gentle transition to excitatory support. The dose of ingredients supporting excitatory neurotransmitters is higher in Procite-D™ than in Contegra. Contegra may be used in the Initial, Restoration or Maintenance phases on the path to patient wellness.
L-theanine as Suntheanine® (standardized to >99%) Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA, and decreasing norepinephrine levels in the brain.*1,2
N-Acetyl-L-Tyrosine Precursor to L-DOPA, the direct precursor to the catecholamines dopamine, norepinephrine and epinephrine.* Acetylated for enhanced bioavailability.
Siberian Ginseng Extract (standardized to 0.8% eleutherosides) Eleutherococcus senticosus, an adaptogen thought to attenuate the effects of stress and fatigue.*3,4
Iodine (as potassium iodide) Essential component of T3 and T4 thyroid hormones.5
Betaine (Trimethylglycine) Methylating agent that supports SAMe production/recycling.*6 SAMe is a co-factor in epinephrine synthesis. Also acts as a source of glycine, an inhibitory amino acid neurotransmitter.*
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®) Cofactor in methylation reactions essential for synthesis of dopamine, norepinephrine and epinephrine.*
Vitamin B6 (as pyridoxal-5’-phosphate): Active form of B6. Cofactor in conversion of L-DOPA to dopamine.*
Vitamin B12 (as Methylcobalamin) Coenzyme form of Vitamin B12.* Methyl donor.*
Pantothenic acid (as pantethine) Biologically active form of Vitamin B5; adrenal support nutrient.*
NeuroSupport Blend™ (NSB) Proprietary mixture composed of Bioperine® and plant-based enzymes clinically proven to maximize nutrient absorption.*
Serving Size: 1 Capsule
Servings per Container: 60 Capsules
Contegra™ Formula 385.85 mg
Vitamin B6 (as pyridoxal-5-phosphate)
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
Vitamin B12 (as methylcobalamin)
Pantothenic Acid (as pantethine)
Iodine (as potassium iodide)
L-theanine (as Suntheanine®)
Siberian Ginseng Extract (std. to 0.8% eleutherosides) (Eleutherococcus senticosus) (stem)
NSB™ Proprietary Blend 102.5mg
BioPerine® (Black Pepper Extract) (standardized to 95% piperine) (Piper nigrum) (fruit)
NSB™ is a trademark of Sanesco International Inc.
BioPerine® is a registered trademark and a product of Sabinsa Corp.
Suntheanine® brand L-Theanine is a registered trademark of Taiyo International, Inc. Suntheanine® is Generally Recognized as Safe (GRAS) & is Non-GMO Project Verified.
Quatrefolic® is a registered trademark of Gnosis S.p.A, U.S. Patent No. 7,947,662
Inhibitory and excitatory neurotransmitter balance is critical for:
- Mental and emotional health
- Calm and relaxation
Adrenal health is important for:
- Stress response
- Weight management
- Menopause & andropause
- Healthy blood sugar regulation
- Mental and emotional health
Thyroid health plays important roles in:
- Weight management7
- Eschenauer G and Sweet BV. Am J Healthy-Syst Pharm. 2006 Jan 1;63(1):26-30.
- Kakuda T, et al. Biosci Biotechnol Biochem. 2002;66(12):2683–2686.
- Kimura Y, Sumiyoshi M. J Ethnopharmacol. 2004 Dec ;95(2-3):447-53.
- Arouca A and Grassi-Kassisse DM. Health. 2013;5(9):1509-1515.
- Iodine. (n.d.). Office of Dietary Supplements (ODS). Retrieved July 1, 2011, from http://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/
- Kempson SA, et al Cell Physiol Biochem. 2013;32(suppl 1):32-40.
- Thinking About Your Thyroid. News in Health. 2015 Sept. Accessed on Aug. 14, 2019. https://newsinhealth.nih.gov/2015/09/thinking-about-your-thyroid
THE 'WIRED & TIRED' FORMULA
L-Theanine (as Suntheanine®)
Shown to promote relaxation by multiple mechanisms including antagonizing glutamate receptors, increasing the release of GABA and decreasing norepinephrine*
Precursor to L-DOPA, the direct precursor to the catecholamines dopamine, norepinephrine and epinephrine.*
Siberian Ginseng Extract
Eleutherococcus senticosus, an adaptogen thought to attenuate the effects of stress and fatigue.*