Tranquilent^TM

Balance between inhibitory and excitatory neurotransmitter activity is vital to health and well-being. Inhibitory neurotransmitters such as serotonin and GABA maintain excitatory signals in the nervous system. That’s why supporting inhibitory neurotransmitters often results in a balanced calming and relaxing effect. 

Tranquilent includes ingredients that support the optimal function of inhibitory neurotransmitter activity.* 5-HTP is a precursor that supports serotonin synthesis.* Myo-inositol works to support healthy serotonergic receptors.*¹ Theanine, as Suntheanine®, intake has been shown to increase GABA activity and function.*

L-theanine as Suntheanine® (standardized to >99%): L-Theanine intake is shown to restore balanced relaxation by balancing multiple internal mechanisms, leading to increased healthy GABA activity while antagonizing glutamate receptors to support balance and decreased norepinephrine activity.*^2,3

5-HTP: A naturally occurring amino acid and metabolite of L–tryptophan. 5-HTP is the direct precursor in the biosynthesis of serotonin.* Use of 5-HTP avoids the rate-limiting conversion of tryptophan to 5-HTP. 

Myo-inositol (inositol) A precursor for the second messenger system (phosphatidyl-inositol) used by noradrenergic, cholinergic and serotonergic receptors.* Inositol regulates numerous healthy cellular functions including optimal membrane and receptor function*¹

Serving Size: 1 Chewable Tablet
Servings per Container: 30 Tablets

Tranquilent™ Formula  1,045mg  
Myo-inositol (inositol)
L-Theanine (as Suntheanine®)
5-hydroxytryptophan (Griffonia simplicifolia) (seed)

Suntheanine® brand L-Theanine is a registered trademark of Taiyo International, Inc.Suntheanine® is Generally Recognized as Safe (GRAS) and is Non-GMO Project Verified. 

GABA and Serotonin are important for: 

• Healthy sleep^4,12
• Balanced calm and relaxation^4,13
  
• Maintaining mood⁴
  
• Regulating excitability⁴
• Mental and emotional health balance (including mood and anxiousness)⁵
• Optimal learning⁵
• Balanced stress response⁵
• Healthy appetite and craving support⁶
• Occasional discomfort and pain⁷
• Healthy libido⁸
• Optimal GI motility⁹
• Thermoregulation balance¹⁰
• Menstrual health¹¹ 

1. Colodny L and Hoffman RL. Altern Med Rev. 1998;3(6):432-447. 
2. Nathan PJ, et al. 2006. J Herb Pharmacother. 6:21–30.
3. Kimura and Morata. Chem Parhm Bull (Tokyo). 1986. Jul; 34 (7) 3053.7.
4. Ngo D and Vo TS. Molecules. 2019;24(15):2678. 
5. Longone P, et al. Frontiers in endocrinology. (2011):2. 
6. Møller SE. (1992). Serotonin, carbohydrates, and atypical depression. Pharmacol Toxicol. 71 Suppl 1:61-71. Slide 19,20 
7. Wurtman J and Wurtman R. Curr Obes. Rep. 2018 Mar;7(1):1-5.
8. Ho KY, et al. Br J Anaesth. 2010 Setp;105(3):371-6.
9. Hull EM, et al. Physiology and Behavior. 2004 Nov;83(2):291-307.
10. Crowell MD. Br J Pharmacol. 2004 Apr;141(8):1285-93.
11. Rybaczy LA, et al. BMC Women’s Health. 2005. 
12. Yonkers KA, et al. ancet. 2008 Apr 5;371(9619):1200-1210.
13. Bravo R, et. al. Age (Dordr). 2013 Aug;35(4):1277-86.
14. Tauscher J, et al. The Amer J of Psychiatry. 2001 Aug 1;158(8):1326-1328.