MethylMax bottle
Targeted Nutritional Therapy™


Comprehensive Methylation Support*

MethylMax™ is a full-spectrum methylation formula for the support of all major methylation pathways.* Methylmax is commonly recommended for patients with an elevated norepinephrine/epinephrine ratio as well as for patients who exhibit decreased stamina and/or low energy.*


Encapsulating the Art & Science of Functional nutrition™

Formula Overview

Methylation plays a vital role in systems throughout the body including:  detoxification of heavy metals, regulation of gene expression, DNA repair, regulation of protein function, and synthesis/metabolism of some neurotransmitters. One of the important biochemical pathways methylation is intimately involved with is the homocysteine/methionine cycle. Homocysteine levels impact cardiovascular health.1,2

MethylMax contains multiple ingredients that support methylation and a healthy homocysteine/methionine cycle.* B vitamins (B6, B9, and B12) help maintain healthy homocysteine metabolism.*3,4 Trimethylglycine (TMG) or betaine and SAMe are methyl donors in the homocysteine cycle.* In fact, TMG methylates homocysteine ultimately generating SAMe.*5

SAMe is the primary methyl donor in the brain.*6 It is a required cofactor in the conversion of norepinephrine to epinephrine and serotonin to melatonin.* Additionally, SAMe is a cofactor for the enzyme catechol-o-methyltransferase, which breaks down catecholamine neurotransmitters.*7

MethylMax may be recommended in conjunction with other TNT products such as Prolent™ and Procite-D™ to support healthy neurotransmitter levels. Given the importance of methylation, MethylMax may be recommended in Initial, Restoration, and Maintenance phases along the path to wellness.


Vitamin B6 (as pyridoxal-5’-phosphate) Active form of B6. Cofactor in the methylfolate cycle and metabolism of homocysteine.*

Folate (as (6S)-5-methyl-tetrahydro folic acid, glucosamine salt) (Quatrefolic®) Active form of B9. Methyl group donor.* Cofactor in methylation reactions essential for the synthesis of dopamine, norepinephrine and epinephrine and break down of homocysteine.*

Vitamin B12 (as Methylcobalamin) Coenzyme form of Vitamin B12.* Methyl donor.* Supports homocysteine metabolism.*

SAMe (s-adenosyl-l-methionine)(as Adomix®) Activated form of a sulfur-containing essential amino acid. Primary methyl donor in the brain*6 Adomix is a room temperature stable form of SAMe.

Betaine (Trimethylglycine) Amino acid that functions as a methyl donor.* Supports SAMe production/recycling.*5

Serving Size: 2 Capsules
Servings Per Container: 30

Methylation™ Formula  420.98 mg
Vitamin B6 (as pyridoxal-5-phosphate)
Folate (as (6S)-5-methyl-tetrahydro folic acid, glucosamine salt) (Quatrefolic®)
Vitamin B12 (as methylcobalamin)
Calcium (as dicalcium phosphate)
SAMe (s-adenosyl-l-methionine)(as Adomix®)
Betaine (Trimethylglycine)

MethylMax™ 1
Quatrefolic® is a registered trademark of Gnosis S.p.A, U.S. Patent No. 7,947,662

Adomix logo
Adomix® is a registered trademark of Gnosis S.p.A.


Methylation is important for:

  • Detoxification of heavy metals
  • Regulation of gene expression
  • DNA repair
  • Regulation of protein function
  • Synthesis/metabolism of some neurotransmitters
  • Maintaining healthy homocysteine levels

SAMe plays roles in:

  • Phospholipid synthesis
  • Low mood8
  • Connective tissue health9
  • Healthy liver function10-12
  • Attention13


  1. Maxwell SRJ. Basic Research in Cardiology. 2000;95(7):I65-I71.
  2. Ganguly P & Alam, SF. Nutrition journal, 2015;14(1):6.
  3. Huang T, et al. Clinical nutrition. 2012;31(4):448-454.
  4. Debreceni B & Debreceni L. Cardiovascular therapeutics, 2014;32(3):130-138.
  5. Barak AJ, Beckenhauer HC, Tuma DJ. (1996 Jul-Aug). Betaine, ethanol, and the liver: a review. Alcohol. 13(4): 395-8.
  6. Bianchi R, et al. Exp Neurol. 1999 Sep.;159(1):258-66.
  7. Gardner A. COMT. Accessed May 11, 2020 at
  8. Young SN and Ghadirian AM. Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(6):841-63.
  9. Di Padova C. Am J Med. 1987 Nov 20;83(5A):60-5.
  10. Di Padova C, et al. Am J Gastroenterol. 1984 Dec ;79(12):941-4.
  11. Mato JM, et al. J Hepatol. 1999 Jun;30(6):1081-9.
  12. Frezza M, et al. Gastroenterology. 1990 Jul ;99(1):211-5.
  13. Shekim WO. Psychopharmacol Bull. 1990;26(2):249-53.


MethylMax bottle-medium-Methylation Neurotransmitter Support Supplement
targeted methylation support

Featured Ingredients

MethylMax™ 2

SAMe (s-adenosyl-l-methionine)(as Adomix®)

Amino Acid

SAMe is the primary methyl donor in the brain and required for synthesis of epinephrine and melatonin.* 


Betaine TMG structure

Betaine (Trimethylglycine)(TMG)

Amino Acid

Betaine, also known as TMG, acts as a methyl donor that supports SAMe production/recycling.*

folate structure

Folate (as Quatrefolic®)


This activated form of vitamin B9 is a cofactor in methylation reactions essential for the synthesis of cateacholamines and breakdown of homocysteine.* 


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