MethylMax™ | 60 tablets
A full-spectrum methylation formula for the support of all major methylation pathways.

*use only under direct supervision of a licensed healthcare provider

A full-spectrum methylation formula for the support of all major methylation pathways.
S-adenosyl-L-methionine: (from S, S S-adenosyl-L-methionine tosylatedisulfate) A primary methyl donor and critical cofactor for all major neurotransmitter biosynthetic pathways, including the final conversion of the catecholamine pathway from Norepinephrine to Epinephrine.

Trimethylglycine: Also known as betaine anhydrous, a major methyl donor.

Vitamin B6 as Pyridoxal-5’-phosphate: Coenzyme form of Vitamin B6 as P5P; critical for neurotransmitter production.

Folate as folic acid: Cofactor in methylation reactions.

Methylcobalamin: Coenzyme form of Vitamin B12; methyl donor; important

SAMe, a primary methyl donor, has extensive scientific validation as an antidepressant, as well as a support for liver function and joint health. SAMe has been used as primary or adjunctive therapy in patients suffering from physical and mental fatigue and depression. Methylation support is suggested when an elevated norepinephrine/epinephrine ratio is reported.

MethylMax™ may be recommended after inhibitory balancing has begun (Prolent™ and Lentra™) but before introducing excitatory support (Contegra™ or ProciteD™), especially in patients with elevated norepi/epi ratio or those indicating issues with blood sugar instability or blood pressure elevation.

No specific contraindications known other than for individuals who are hypersensitive to any of the MethylMax™ ingredients. Caution should be exercised, however, when using SAMe in patients with a known history of bipolar disorder or any form of manic depression or psychosis.

Featured Ingredients

B12 Vitamin

Methylcobalamin is a coenzyme form of B12, which is the activated form necessary for nervous system health

B9 | Folate

5-methyltetrahydrofolate, involved in the biosynthesis of nucleotides purines and pyrimidines and in the metabolism of several important amino acids.

B6 Vitamin

Vitamin B6 in the Pyridoxal-5’-phosphate (P5P) form is one of the most crucial vitamin cofactors to the biosynthetic pathways of many
neurotransmitters

The Natural Process

MethylMax pathway-01 Folate-requiring reactions, collectively referred to as one-carbon metabolism, include those involved in phases of amino acid metabolism, purine and pyrimidine synthesis, and the formation of the primary methylating agent, S-adenosylmethionine (SAM).

The central folate acceptor molecule in the one-carbon cycle is a polyglutamyl form of tetrahydrofolate (THF) (Wagner 1995). The principal function of folate coenzymes is to accept or donate one-carbon units in key metabolic pathways. The conversion of THF to 5,10-methylene-THF is a crucial first step in the cycle that employs the 3-carbon of serine as a major carbon source. This one-carbon unit is transferred from serine to THF via pyridoxal phosphate (PLP)-dependent serine hydroxymethyltransferase (SHMT) to form 5,10-methylene-THF and glycine.

A portion of the 5,10-methylenetetrahydrofolate thus produced undergoes irreversible enzymatic reduction to the methyl oxidation state (as 5-methyl-THF) by methylene tetrahydrofolate reductase (MTHFR). The N-5 methyl group of 5-methyl-THF can only be used metabolically for transfer to homocysteine, which results in the (re)generation of methionine.

MTHFR serves a key role in one-carbon metabolism by converting methylene-THF to 5-methyl-THF, thus irreversibly directing this one-carbon moiety to methylation of homocysteine synthesis. Between 50 and 80% of the homocysteine generated is remethylated, depending on the dietary content of methionine and choline. In the methionine synthase reaction, a methyl group is removed from 5-methyl-THF, which functions as a substrate, and is sequentially transferred to the vitamin B-12 coenzyme before homocysteine, thus forming methionine.

In addition to protein synthesis, methionine serves as a methyl group donor through conversion to SAM, a key biological methylating agent involved in >100 methyltransferase reactions with a wide variety of acceptor molecules. (source)

Patient Testimonial

Marci | Illinois

MethylMax is the best product for those wanting to take SAM-e. I am one of the few people who get digestive upset when taking SAM-e, in my case it’s ulcer-like symptoms. MethylMax was recommended by my doctor as part of my treatment plan to overcome adrenal fatigue, depression and hypothyroid.

Patient Testimonial

Kelly | California

I have been taking MethylMax for several years. I can tell a big difference in my mood when I stop taking it for any length of time.