MethylMax^TM

Methylation plays a vital role in systems throughout the body including:  detoxification of heavy metals, regulation of gene expression, DNA repair, regulation of protein function, and synthesis/metabolism of some neurotransmitters. One of the important biochemical pathways methylation is intimately involved with is the homocysteine/methionine cycle. Homocysteine levels impact cardiovascular health.^1,2

MethylMax contains multiple ingredients that support methylation and a healthy homocysteine/methionine cycle.* B vitamins (B6, B9, and B12) help maintain healthy homocysteine metabolism.*^3,4 Trimethylglycine (TMG) or betaine and SAMe are methyl donors in the homocysteine cycle.* In fact, TMG methylates homocysteine ultimately generating SAMe.*⁵

SAMe is the primary methyl donor in the brain.*⁶ It is a required cofactor in the conversion of norepinephrine to epinephrine and serotonin to melatonin.* Additionally, SAMe is a cofactor for the enzyme catechol-o-methyltransferase, which breaks down catecholamine neurotransmitters.*⁷

MethylMax may be recommended in conjunction with other TNT products such as Prolent™ and Procite-D™ to support healthy neurotransmitter levels. Given the importance of methylation, MethylMax may be recommended in Initial, Restoration, and Maintenance phases along the path to wellness.

Vitamin B6 (as pyridoxal-5’-phosphate) Active form of B6. Cofactor in the methylfolate cycle and metabolism of homocysteine.*

Folate (as (6S)-5-methyl-tetrahydro folic acid, glucosamine salt) (Quatrefolic®) Active form of B9. Methyl group donor.* Cofactor in methylation reactions essential for the synthesis of dopamine, norepinephrine and epinephrine and break down of homocysteine.*

Vitamin B12 (as Methylcobalamin) Coenzyme form of Vitamin B12.* Methyl donor.* Supports homocysteine metabolism.*

SAMe (s-adenosyl-l-methionine)(as Adomix®) Activated form of a sulfur-containing essential amino acid. Primary methyl donor in the brain*⁶ Adomix is a room temperature stable form of SAMe.

Betaine (Trimethylglycine) Amino acid that functions as a methyl donor.* Supports SAMe production/recycling.*⁵

Serving Size: 2 Capsules
Servings Per Container: 30

Methylation™ Formula  420.98 mg
Vitamin B6 (as pyridoxal-5-phosphate)
Folate (as (6S)-5-methyl-tetrahydro folic acid, glucosamine salt) (Quatrefolic®)
Vitamin B12 (as methylcobalamin)
Calcium (as dicalcium phosphate)
SAMe (s-adenosyl-l-methionine)(as Adomix®)
Betaine (Trimethylglycine)

Quatrefolic® is a registered trademark of Gnosis S.p.A, U.S. Patent No. 7,947,662

Adomix® is a registered trademark of Gnosis S.p.A.

Methylation is important for:

• Detoxification of heavy metals
• Regulation of gene expression
• DNA repair
• Regulation of protein function
• Synthesis/metabolism of some neurotransmitters
• Maintaining healthy homocysteine levels

SAMe plays roles in:

• Phospholipid synthesis
• Low mood⁸
• Connective tissue health⁹
• Healthy liver function^10-12
• Attention¹³

1. Maxwell SRJ. Basic Research in Cardiology. 2000;95(7):I65-I71.
2. Ganguly P & Alam, SF. Nutrition journal, 2015;14(1):6.
3. Huang T, et al. Clinical nutrition. 2012;31(4):448-454.
4. Debreceni B & Debreceni L. Cardiovascular therapeutics, 2014;32(3):130-138.
5. Barak AJ, Beckenhauer HC, Tuma DJ. (1996 Jul-Aug). Betaine, ethanol, and the liver: a review. Alcohol. 13(4): 395-8.
6. Bianchi R, et al. Exp Neurol. 1999 Sep.;159(1):258-66.
7. Gardner A. COMT. Accessed May 11, 2020 at https://www.mygenefood.com/genes/brain-and-mental-health-genes/comt/#references
8. Young SN and Ghadirian AM. Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(6):841-63.
9. Di Padova C. Am J Med. 1987 Nov 20;83(5A):60-5.
10. Di Padova C, et al. Am J Gastroenterol. 1984 Dec ;79(12):941-4.
11. Mato JM, et al. J Hepatol. 1999 Jun;30(6):1081-9.
12. Frezza M, et al. Gastroenterology. 1990 Jul ;99(1):211-5.
13. Shekim WO. Psychopharmacol Bull. 1990;26(2):249-53.