SomniTR^TM

Reduced melatonin activity can contribute to prolonged sleep latency, inability to stay asleep, and overall disruption to healthy circadian rhythms, including occasional  jet lag.¹ Circadian rhythm imbalances are hypothesized to contribute to increased appetite and weight gain.²

SomniTR provides melatonin and also provides support for healthy GABA-A receptor sites function.* Lactium have been shown to improve quality of optimal sleep by supporting GABA-A receptor activity.*³ ForsLean supports cAMP⁴ while pantothenic acid supports acetyl coenzyme A,⁵ both of which are important in healthy melatonin synthesis.*⁶

SomniTR contains ingredients that support melatonin production by supplementing multiple steps in the serotonin-to-melatonin pathway, and influencing balanced inhibitory GABAergic activity to impact multiple functional pathways connected to healthy sleep.* 

Lactium® Acts as a GABA-A receptor agonist, maintaining healthy receptor activity.*⁷ Lactium has been shown to decrease stress-related symptoms for balance in women and significantly improve healthy sleep quality.*^3,7

ForsLean® (standardized to 20% forskolin) a source of forskolin that increases healthy cAMP activity.*⁴ Serotonin N-acetyltransferase requires cAMP to metabolize serotonin to N-acetylserotonin, the immediate precursor to melatonin.⁶

Pantethine Precursor to acetyl coenzyme A.*² Production of N-acetylserotonin requires acetyl coenzyme A.⁶

Calcium (as Dicalcium Phosphate) potentiates the effects of cAMP.* Serotonin N-acetyltransferase requires cAMP to convert serotonin to the precursor to melatonin.⁵

Melatonin is a neurohormone involved with balanced circadian rhythm regulation and sleep induction.*²

Serving Size: 1 Tablet
Servings Per Container: 30 Tablets

SomniTR™ Formula  197mg  
Pantothenic Acid (as pantethine)
ForsLean® (Coleus forskohlii extract) (standardized for 20% forskolin) (root)
Lactium®
Melatonin

Lactium® is a registered trademark used under license and is protected under U.S. patent #5,846,939.

ForsLean® is a registered trademark of Sabinsa Corporation and is the only Coleus forskohlii preparation supported commonly by Patent.

GABA balance is vital for: 

• Optimal sleep⁹
  
• Balanced calm and relaxation⁹
• Healthy mood⁹
  
• Regulating excitability⁹
  

Melatonin activity is critical for: 

• Optimal sleep^1,6

1. Zisapel N. British Journal of Pharmacology. 2018;175: 3190-3199.
2. Hardeland R, et al. Progress in Neurobiology. 2011; 93(3), 350-384.11. 
3. de Saint-Hilaire ZD, et al. The Open Sleep Journal. 2009;3, 26-32.  
4. Allen DO and Quesenberry JT. Journal of Pharmacology and Experimental Therapeutics.1988;244(3):852-858.
5. Horvath Z and Vecsel L. Journal of Evidence-based Complementary & Alternative Medicine. 2011;16(1):21-28. 
6. Klein DC, et al. Recent. Prog. Horm. 1997;52:307-357. 
7. Miclo L, et al. The FASEB Journal express article. Published online 2001 Jun 8.
8. Kim JH, et al. European Journal of Clinical Nutrition. 2007;61:536-541.
9. Ngo D and Vo TS. Molecules. 2019;24(15):2678.