Stress and Sleep
In a sea of stressed-out people with poor sleep concerns, Lactium® stands out as part of the solution for optimal sleep. In many cases, chronic and/or acute stress can interfere with healthy sleep patterns, worsening sleep latency, quality, and duration. Additionally, the most prevalent forms of insomnia are associated with stress, as well as anxiety and depression. 
Origin of Lactium®
Lactium® is a natural ingredient that may be used in supplements to moderate stress and promote calmness. It is a bioactive peptide with soothing properties that comes from milk. [8, 9]
Lactium®’s story begins with French researchers on the hunt to find out what contributes to the calmness of infants after drinking mother’s milk. The researchers hypothesized that some aspect of the milk itself may contribute to its relaxing results. They successfully identified a bioactive peptide in milk with calming properties. 
The bioactive peptide in Lactium® comes from casein, a milk protein. However, drinking a glass of milk does not necessarily result in the same effect as Lactium®. The Lactium® peptide is encrypted, or hidden in a protein called αS1 casein. The digestive environment of infants can release the peptide, but adult’s enzymatic systems are more complex and digest it differently. 
Researchers found a way to isolate the Lactium® peptide, allowing it to be effective for older children and adults. Lactium® has a unique structure that may help it cross biological barriers such as the intestinal barrier and the blood-brain barrier. [3, 4, 9]
How does Lactium® work?
Lactium® has a complex mechanism of action. However, research has proved that it has an affinity for GABAA receptors. These receptors are involved in reducing anxiety. GABA is the main inhibitory neurotransmitter, working with serotonin to promote a sense of well-being, calmness, good mood, and optimal sleep, as well as modulating the excitatory system. Stimulating the GABAA receptors can help produce these effects. [3, 4, 6, 7, 9]
Lactium®: A Safe Ingredient
Although it comes from milk, Lactium® does not pose a risk for people with lactose intolerance. The lactose content is around 1%, and average daily doses of Lactium® are around 150 mg. As even severely lactose intolerant people can consume up to 5g/day of lactose, Lactium® should not provoke any negative effects. Furthermore, Lactium® does not contain ß-lactoglobulin, one of the most allergenic proteins that come from milk. Additionally, Lactium® is a hydrolysate, which is hypoallergenic. This means that the milk protein has been broken down to the point that the body’s immune system is unlikely to recognize the protein as an allergen. 
Lactium®’s effect on the GABAA receptors is similar to that of benzodiazepines, a class of drugs including Xanax® and Klonopin. However, unlike benzodiazepines, Lactium® does not cause any side effects, addiction, weight gain, tolerance, or sedation. Lactium® is a natural, food-grade ingredient recognized by the FDA. It is also a kosher and non-GMO ingredient. [3, 4, 7, 9]
Lactium®, Stress, and Sleep: Clinical studies
In clinical studies, Lactium® has been shown to chronically aid in blood pressure and heart rate regulation during and after a stressful situation, and may have a positive effect on cortisol levels during stress. [2, 5, 9] Another study found Lactium® effective for acute stress management, showing significant reduction in systolic blood pressure and heart rate during stress. This effect was noted in as little as two weeks after beginning to take it, and the effects were still significant six weeks later. [2, 5] Lactium® has also been shown to improve sleep quality, sleep latency (the time it takes to fall asleep), and daytime dysfunction. 
In a study on physiological, psychological, and social-related stress, people consuming Lactium® showed improvements in stress-related digestive, cardiovascular, intellectual, emotional, and social concerns. The study’s self-reported measures show that, in addition to showing physiological improvements, the positive effects of Lactium® are verified by people who use it. [2, 5]
Lactium®’s effectiveness is not derived from suppressing the stress response. Instead, it promotes relaxation that helps people deal with occasional or everyday stress. This stress-relieving action can be utilized to improve sleep quality. If the stress during the day and/or before bedtime is lessened, sleep quality may be enhanced. Lactium® has been shown to be physiologically effective around an hour after ingestion. Although it may differ from person to person, the calming effect of Lactium® is often noted within 7 to 15 days with regular doses. [1, 9]
If you struggle with stress and suboptimal sleep, consider discussing sleep-support supplements containing Lactium®, such as SomniTR™, with your healthcare practitioner.
- de Saint-Hilaire, Z., Messaoudi, M., Desor, D., & Kobayashi, T. (2009). Effects of a bovine alpha S1-Casein tryptic hydrolysate (CTH) on sleep disorder in Japanese general population.Open Sleep Journal,2, 26-32.
- Lanoir D. (et Al.), Long term effects of a bovine milk alpha-S1 casein hydrolysate on healthy low and high stress responders. Stress, 5 (suppl.), 124, (2002) 3. Lecouvey, M., Frochot, C., Miclo, L., Orlewski, P., Driou, A., Linden, G., … & Vanderesse, R. (1997). Two‐Dimensional 1H‐NMR and CD Structural Analysis in a Micellar Medium of a Bovine αs1‐Casein Fragment having Benzodiazepine‐Like Properties.The FEBS Journal, 248(3), 872-878.
- Lecouvey, M., Frochot, C., Miclo, L., Orlewski, P., Marraud, M., Gaillard, J. L., … & Vanderesse, R. (1997). Conformational studies of a benzodiazepine-like peptide in SDS micelles by circular dichroism, 1 H NMR and molecular dynamics simulation.Letters in Peptide Science,4(4), 359-364.
- Messaoudi, M., Lefranc–Millot, C., Desor, D., Demagny, B., & Bourdon, L. (2005). Effects of a tryptic hydrolysate from bovine milk α S1–casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations.European journal of nutrition,44(2), 128-132.
- Miclo, L., Perrin, E., Driou, A., Papadopoulos, V., Boujrad, N., Vanderesse, R., … & Gaillard, J. L. (2001). Characterization of α-casozepine, a tryptic peptide from bovine αs1-casein with benzodiazepine-like activity.The FASEB Journal,15(10), 1780-1782.
- Violle, N., Messaoudi, M., Lefranc-Millot, C., Desor, D., Nejdi, A., Demagny, B., & Schroeder, H. (2006). Ethological comparison of the effects of a bovine α S1-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety.Pharmacology Biochemistry and Behavior,84(3), 517-523.
- U.S. Food & Drug Administration. New Dietary Ingredient Notification for lactium®.
- FAQ lactium®®. (2007, January). Retrieved from http://lactium®info.com//wp-content/uploads/2016/03/frequently-asked-questions.pdf
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Disclaimer: The information provided is only intended to be general educational information to the public. It does not constitute medical advice. If you have specific questions about any medical matter or if you are suffering from any medical condition, you should consult your doctor or other professional healthcare provider.